Study Overview
In male pattern hair loss (Androgenetic Alopecia (AGA)), testosterone, a type of male hormone, is converted into DHT (dihydrotestosterone), and when DHT binds to the male hormone receptors of hair follicle papilla cells, it induces the production of hair loss factors such as DKK-1 and TGF-β. These send commands to hair matrix cells to stop hair growth, shortening the anagen phase, causing hair to become thinner and more likely to fall out, leading to hair thinning.
In this study, we verify whether the test substance inhibits the increased production of hair loss factors stimulated by male hormones using human dermal papilla cells.
For analysis of samples expected to have anti-androgenic activity, we recommend the male pattern hair loss (AGA) suppression study.
For analysis of samples expected to have hair growth promoting effects, we recommend the dermal papilla cell activation study.
Study Example
Compound B suppresses the production of hair loss factors
Basic Experimental design
| Cells used | Human hair follicle dermal papilla cells (HFDPC) |
|---|---|
| Preliminary study | Cytotoxicity assay |
| Main study | Measurement of hair loss factor production (ELISA) |
*Studies will be mainly conducted by those with doctoral degrees.
