Study Overview
Epidermal keratinocytes, found on the skin’s outermost layer, protect against dehydration and UV rays. Stressors like oxidation and UV radiation can cause damage to these keratinocytes, leading to skin disorders. As such, studying these cells are important for the development of cosmetics capable of preventing damage to keratinocytes.
This study examines the effects of a test substance on cell activation and stress protection in epidermal keratinocytes. The objective of this study is to screen and validate new functional substances that are able to protect the skin from UV, oxidation and other stressors.
Study example
Basic Experimental design
| Cells used | Normal human epidermal keratinocytes, Normal human fibroblasts, etc. |
|---|---|
| Preliminary study | Cytotoxicity assay |
| Main study | Measurement of cell viability (e.g, cell counting using WST-8 or Cell-titer glo) after exposure to oxidative stress and ultraviolet radiation Oxidative stress and ultraviolet (UV) radiation avoidance tests, etc. |
*All our studies are mainly performed and handled by our team of PhD scientists.
