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Vascular function improvement study using vascular endothelial cells (antithrombotic effect evaluation)

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Study Overview

Thrombosis (blood coagulation), one of the causes of cerebral infarction and myocardial infarction, occurs when a blood clot forms in a blood vessel, blocking blood flow. Antithrombotic factors known to improve thrombosis include prostacyclin (PGI2), nitric oxide (NO), eNOS (nitric oxide synthase), which have vasodilatory properties, as well as thrombomodulin, which is present in vascular endothelial cells. In this study, the expression levels of these antithrombotic factors will be measured to verify the test substance’s ability to improve vascular function (antithrombotic and vasodilatory effects).

Study example

Basic Experimental design

Cells usedNormal human umbilical vein endothelial cells (HUVEC), HAoEC, etc.
Preliminary studyCytotoxicity assay
Main studyProstacyclin production measurement
NO production measurement
Thrombomodulin, eNOS gene expression analysis, etc.



*Studies will be mainly conducted by those with doctoral degrees.