Study Overview
Similar to the 2D cell model of measuring melanin production, this study uses a 3D model to evaluate the inhibition of melanin production by test substances. One key aspect of this model is that it contains melanocytes, allowing epidermal-melanoctye cellular communication. Compared to a 2D model, the 3D model is a closer representation of the human condition owing to the intercellular communication between epidermal cells and melanocytes. Through this cellular architecture, the process of melanosome transfer from melanocytes to epidermal cells can be observed. For more information on our 2D melanin assay, click here.
Study example
Basic Experimental design
| Skin model used | Three-dimensional melanin-containing human skin model (MeranoDerm MEL-300), etc. |
|---|---|
| Preliminary study | Cytotoxicity assay |
| Main study | Observation of melanosis, measurement of melanin production through alkaline lysis |
*All our studies are mainly performed and handled by our team of PhD scientists.
