Dr. Ishihara and Dr. Haga’s research group focused on the “stiffness” of cancer and found that pancreatic and lung cancer cells grown on stiff scaffolds activated ATF5, enhancing cell proliferation.These research results suggest that ATF5 may be a new target for the treatment of intractable pancreatic and lung cancers.
Our company conducted drug screening and supported the identification of candidate compounds that regulate the nuclear localization of ATF5 from among 500 compounds using a high-content screening instrument (Operetta CLS).
Hokkaido University School of Science Research News
Hokkaido University PRESS RELEASE (March 13, 2025)
[Journal Name]
iScience
[Article Title]
Stiff extracellular matrix activates the transcription factor ATF5 to promote the proliferation of cancer cells
[Authors]
Seiichiro Ishihara, Atsushi Enomoto, Akihiro Sakai, Tadashi Iida, Shoichiro Tange, Noriyuki Kioka, Akihiro Nukuda, Ayaka Ichikawa Nagasato, Motoaki Yasuda, Takashi Tokino, Hisashi Haga
