Study Overview
IgA (immunoglobulin A) is an immune substance present in mucous membranes that binds to and neutralizes various pathogens and viruses, including influenza viruses, preventing their entry into the body. IgA is primarily produced when B cells present in the Peyer’s patches in the intestinal tract become IgA-producing cells. These IgA-producing cells then migrate to mucous membranes throughout the body, such as the mouth and nose, and contribute to the prevention of infectious diseases. Therefore, substances that increase IgA production are thought to contribute to the prevention of various infectious diseases.
This study evaluates the ability to promote IgA production in Peyer’s patch cells. Furthermore, our proprietary test system enables us to evaluate substances that promote not only B cell proliferation but also IgA class switching, enabling us to discover food ingredients that enhance IgA production in the intestinal tract and evaluate immune adjuvants. The effects of not only B cell growth factors such as LPS but also Poly (I:C) (double-stranded RNA) can be analyzed.
Study example
Basic Experimental design
| Cells used | Mouse intestinal Peyer’s patch cells |
|---|---|
| Measurement items | IgA production |
*Studies will be mainly conducted by those with doctoral degrees.
