Study Overview
Hair papilla cells play an important role in hair development and growth by supporting the metabolism of actively dividing hair matrix cells. For example, fibroblast growth factor 7 (FGF-7) is secreted from dermal papilla cells, which stimulates cell division in hair matrix cells. Dermal papilla cells also secrete vascular endothelial growth factor (VEGF), which is thought to promote angiogenesis, thereby ensuring a sufficient supply of necessary nutrients and facilitating hair formation.
This study will verify the cell-activating effects of test substances using dermal papilla cells, with the aim of verifying and discovering new functional substances with hair growth and hair regrowth effects. In addition to measuring cell proliferation rates, the production levels of FGF-7 and VEGF, which are involved in promoting hair growth, will be measured.
Basic Experimental design
| Cells used | Human dermal papilla cells |
|---|---|
| Preliminary study | Cytotoxicity assay |
| Main study | Cell proliferation rate measurement FGF-7 and VEGF production measurement (ELISA) |
*Studies will be mainly conducted by those with doctoral degrees.
