Study Overview
Small interfering RNA (siRNA) is a class of double-stranded, non-coding RNA molecules silence specific genes by degrading complementary mRNA via the RNA interference (RNAi) pathway. Utilizing this advanced gene expression suppression (knockdown) technology, which is widely applied in cancer research, disease screening, and nucleic acid medicine, we offer custom gene knockdown services in various cell lines tailored to your requests.
Principle of siRNA-mediated knockdown
When double-stranded siRNA is introduced into cells, one strand (single-stranded RNA) binds with the Argonaute protein to form a RNA-induced silencing complex (RISC). This single-stranded RNA acts as a guide, directing the RISC to complementary mRNA sequences. The complex then degrades the target mRNA, resulting in gene knockdown.
*All our studies are mainly performed and handled by our team of PhD scientists.
