Study Overview
Cancer cells that develop in epithelial tissue invade by destroying the basement membrane and metastasize to normal tissue. The invasion process involves steps such as cell adhesion to the basement membrane, degradation of the extracellular matrix, and cell migration.
This study uses a basement membrane model, which makes it possible to measure the number of invaded cancer cells with high sensitivity and verifies whether the test substance inhibits cancer cell invasion. It is also possible to screen multiple test substances.
Basic Experimental design
| Cells used | Human fibrosarcoma cells (HT-1080), and various other cells |
|---|---|
| Preliminary study | Cytotoxicity assay |
| Main study | Measurement of the number of invaded cancer cells |
*Studies will be mainly conducted by those with doctoral degrees.
