Study Overview
Inhibiting the invasion of cancer cells is beneficial for preventing cancer metastasis.
Cancer metastasis is the spread of cancer cells to other parts of the body, a process heavily reliant on cell invasion into surrounding tissues. This cellular process begins when epithelial cancer cells destroy the basement membrane, followed by adhesion to the membrane, degradation of the extracellular matrix, and subsequent cell migration to normal tissue. Therapeutics that are able to prevent the cellular invasion of cancer cells are of strong interest as anti-metastatic drugs.
This study uses a basement membrane model to evaluate the invasion of cancer cells across a basement membrane. It is a highly sensitive approach to evaluate whether test substances are able to inhibit cancer cell invasion. This approach also allows for the screening of multiple test substances simultaneously.
Basic Experimental design
| Cells used | Human fibrosarcoma cells (HT-1080), and various other cells |
|---|---|
| Preliminary study | Cytotoxicity assay |
| Main study | Measurement of the number of invaded cancer cells |
*All our studies are mainly performed and handled by our team of PhD scientists.
